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- Extra Pain Relief ANUSOL with the added benefit of a topical anesthetic to help relieve the pain and itching. Each white, opaque suppository contains: pramoxine hydrochloride 20 mg and zinc sulfate monohydrate 10 mg. Non-medicinal ingredients: calcium phosphate, magnesium stearate, parabens and vegetable oil. Boxes of 12 . Indications: Relieves the pain and discomfort of internal hemorrhoids.